Cartilage repair in an osteochondral defect in a rabbit model

Using Xenogenic (Calf Foetal) Osteochondral Transplantation for Articular Cartilage Defect in Rabbit Model

Background: The destruction of articular cartilage is the major cause of articular problems. The articular cartilage has little repair postertial due to lack of perichondrium and direct blood circulation. It is, therefore important to consider this phenomena in surgical treatments. One of the articular cartilage reconstructive surgeries is using Osteo-Chondral graft. The main purpose of this re...

Use of allogeneic scaffold-free chondrocyte pellet in repair of osteochondral defect in a rabbit model.

Cell-based therapies are currently being used in treating osteochondral defect (OCD), but technical advances are needed to tackle the problems of scaffold and grafting technique. This study aimed to test the potential of allogeneic scaffold-free bioengineered chondrocyte pellet (BCP) in treating OCD. BCP was fabricated from rabbit costal cartilage and implanted into 3 mm × 3 mm OCD in medial fe...

Peripheral Blood Mononuclear Cells Enhance Cartilage Repair in in vivo Osteochondral Defect Model

This study characterized peripheral blood mononuclear cells (PBMC) in terms of their potential in cartilage repair and investigated their ability to improve the healing in a pre-clinical large animal model. Human PBMCs were isolated with gradient centrifugation and adherent PBMC's were evaluated for their ability to differentiate into adipogenic, chondrogenic and osteogenic lineages and also fo...

the healing effect of bioglue in articular cartilage defect of femoral condyle in experimental rabbit model

Cartilage constructs engineered from chondrocytes overexpressing IGF-I improve the repair of osteochondral defects in a rabbit model.

Tissue engineering combined with gene therapy is a promising approach for promoting articular cartilage repair. Here, we tested the hypothesis that engineered cartilage with chondrocytes overexpressing a human insulin-like growth factor I (IGF-I) gene can enhance the repair of osteochondral defects, in a manner dependent on the duration of cultivation. Genetically modified chondrocytes were cul...